Masahide Takahashi Selected Research

Glial Cell Line-Derived Neurotrophic Factor (GDNF)

6/2011	Analysis of glial cell line-derived neurotrophic factor-inducible zinc finger protein 1 expression in human diseased kidney.
5/2010	Analysis of DOK-6 function in downstream signaling of RET in human neuroblastoma cells.
2/2008	A novel GDNF-inducible gene, BMZF3, encodes a transcriptional repressor associated with KAP-1.
9/2007	RET signaling-induced SPHK1 gene expression plays a role in both GDNF-induced differentiation and MEN2-type oncogenesis.
6/2007	Sprouty2 regulates growth and differentiation of human neuroblastoma cells through RET tyrosine kinase.
8/2006	Dok-4 regulates GDNF-dependent neurite outgrowth through downstream activation of Rap1 and mitogen-activated protein kinase.
7/2005	Activation of c-Jun amino-terminal kinase by GDNF induces G2/M cell cycle delay linked with actin reorganization.
10/2004	Biochemical and biological responses induced by coupling of Gab1 to phosphatidylinositol 3-kinase in RET-expressing cells.
7/2004	Induction of CRMP-2 by GDNF and analysis of the CRMP-2 promoter region.
7/2002	Characterization of gene expression induced by RET with MEN2A or MEN2B mutation.

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Masahide Takahashi Research Topics

Disease

49	Neoplasms (Cancer) 04/2022 - 01/2002
9	Squamous Cell Carcinoma (Epidermoid Carcinoma) 12/2016 - 04/2004
8	Multiple Endocrine Neoplasia Type 2a (MEN 2) 01/2022 - 04/2002
8	Neuroblastoma 06/2011 - 07/2002
5	Thyroid Neoplasms (Thyroid Cancer) 01/2022 - 06/2002
5	Breast Neoplasms (Breast Cancer) 09/2015 - 03/2008
5	Multiple Endocrine Neoplasia (Multiple Endocrine Adenomatosis) 10/2004 - 09/2002
4	Keratoconus 01/2022 - 01/2018
4	Neoplasm Metastasis (Metastasis) 01/2021 - 03/2008
4	Lung Neoplasms (Lung Cancer) 12/2020 - 05/2012
3	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 01/2022 - 09/2003
3	Hirschsprung Disease (Hirschsprung's Disease) 01/2022 - 02/2004
3	Astigmatism 09/2021 - 03/2018
3	Adenocarcinoma 10/2019 - 04/2005
3	Glioma (Gliomas) 01/2019 - 01/2017
3	Glioblastoma (Glioblastoma Multiforme) 01/2019 - 04/2015
3	Lymphatic Metastasis 02/2016 - 03/2013
3	Schizophrenia (Dementia Praecox) 08/2015 - 09/2009
3	Vascular Remodeling 01/2015 - 05/2011
3	Primitive Neuroectodermal Tumors (PNET) 09/2014 - 06/2002
3	Carcinoma (Carcinomatosis) 05/2014 - 01/2002
3	Carcinogenesis 11/2010 - 09/2007
3	Papillary Thyroid Cancer 05/2010 - 06/2002
3	Multiple Endocrine Neoplasia Type 2b (MEN 3) 02/2004 - 07/2002
2	Fibrosis (Cirrhosis) 12/2021 - 01/2021
2	Colonic Neoplasms (Colon Cancer) 01/2021 - 01/2020
2	Myocardial Infarction 01/2019 - 11/2015
2	Presbyopia 01/2018 - 12/2017
2	Hyperplasia 01/2015 - 08/2014
2	Infections 02/2014 - 11/2002
2	Melanoma (Melanoma, Malignant) 01/2010 - 02/2004
2	Malignant Mesothelioma 01/2004 - 09/2003
1	Pancreatic Neoplasms (Pancreatic Cancer) 03/2022
1	Colitis 01/2022
1	Cachexia 01/2022
1	Hyperopia (Hypermetropia) 01/2022
1	Body Weight (Weight, Body) 01/2022
1	Anorexia 01/2022
1	Pulmonary Fibrosis (Fibrosing Alveolitis) 12/2021
1	Thyroiditis 12/2021
1	Refractive Errors (Refractive Error) 01/2021
1	Colorectal Neoplasms (Colorectal Cancer) 01/2021
1	Squamous Cell Carcinoma of Head and Neck 01/2021

Drug/Important Bio-Agent (IBA)

30	Proteins (Proteins, Gene)FDA Link 03/2022 - 07/2002
12	Glycosylphosphatidylinositols (Glycosyl-Phosphatidylinositol)IBA 04/2022 - 10/2008
12	Glial Cell Line-Derived Neurotrophic Factor (GDNF)IBA 06/2011 - 01/2002
8	Glycoproteins (Glycoprotein)IBA 04/2022 - 10/2008
8	Protein-Tyrosine Kinases (Tyrosine Kinase)IBA 10/2020 - 06/2002
6	Microfilament Proteins (Actin Binding Proteins)IBA 11/2020 - 03/2008
5	Biological ProductsIBA 03/2022 - 05/2003
5	Phosphotransferases (Kinase)IBA 01/2022 - 04/2002
5	Biomarkers (Surrogate Marker)IBA 01/2021 - 09/2014
4	Receptor Protein-Tyrosine Kinases (Tyrosine Kinase Receptors)IBA 01/2022 - 01/2002
4	CollagenIBA 01/2021 - 11/2015
4	Small Interfering RNA (siRNA)IBA 08/2014 - 08/2006
4	Tyrosine (L-Tyrosine)FDA Link 03/2012 - 05/2007
3	Pharmaceutical PreparationsIBA 01/2022 - 01/2010
3	AntibodiesIBA 12/2021 - 05/2008
3	EnzymesIBA 01/2021 - 09/2007
3	Collagen Type I (Type I Collagen)IBA 01/2019 - 07/2002
3	Carrier Proteins (Binding Protein)IBA 06/2015 - 04/2009
3	IntegrinsIBA 05/2014 - 10/2009
3	ParaffinIBA 10/2009 - 01/2002
2	CytokinesIBA 01/2022 - 02/2014
2	RNA (Ribonucleic Acid)IBA 12/2021 - 03/2008
2	Oxygen (Dioxygen)IBA 10/2020 - 02/2013
2	Transforming Growth Factors (Transforming Growth Factor)IBA 01/2019 - 03/2013
2	Temozolomide (Temodar)FDA LinkGeneric 01/2019 - 12/2017
2	Arginine Vasopressin (Argipressin)IBA 01/2018 - 12/2011
2	Serine (L-Serine)FDA Link 11/2015 - 05/2011
2	Vasopressins (Vasopressin)IBA 12/2014 - 12/2011
2	Cisplatin (Platino)FDA LinkGeneric 05/2014 - 04/2009
2	Complementary DNA (cDNA)IBA 03/2013 - 11/2002
2	Endothelin Receptors (Endothelin Receptor)IBA 07/2010 - 01/2010
2	Formaldehyde (Formol)FDA Link 10/2009 - 05/2008
2	Phenylalanine (L-Phenylalanine)FDA Link 04/2004 - 04/2002
2	beta CateninIBA 01/2004 - 09/2003
1	Bromodeoxyuridine (BrdU)IBA 01/2022
1	Immune Checkpoint InhibitorsIBA 01/2022
1	LigandsIBA 01/2022
1	tamibaroteneIBA 01/2022
1	Bleomycin (Blenoxane)FDA LinkGeneric 12/2021
1	Small Cytoplasmic RNAIBA 12/2021
1	Thyroglobulin FDA Link 12/2021
1	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 01/2021
1	Leucine (L-Leucine)FDA Link 01/2021
1	ImmunosorbentsIBA 01/2021
1	Immunoglobulins (Immunoglobulin)IBA 01/2021
1	LuciferasesIBA 01/2021
1	ElastinIBA 01/2021
1	Bone Morphogenetic Proteins (Bone Morphogenetic Protein)IBA 01/2021

Therapy/Procedure

15	Therapeutics 01/2022 - 04/2004
4	Phakic Intraocular Lenses 09/2021 - 12/2017
4	Lasers (Laser) 01/2019 - 12/2003
3	Drug Therapy (Chemotherapy) 09/2015 - 10/2004
2	Corneal Cross-Linking 10/2020 - 01/2018
2	Immunotherapy 11/2010 - 02/2004
1	Contact Lenses 01/2022
1	Keratectomy 01/2022
1	Hydrophilic Contact Lenses (Hydrophilic Contact Lens) 01/2022